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Titel:

Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer's disease.

Dokumenttyp:
Clinical Trial; Controlled Clinical Trial; Journal Article; Article
Autor(en):
Riemenschneider, M; Mahmoodzadeh, S; Eisele, T; Klopp, N; Schwarz, S; Wagenpfeil, S; Diehl, J; Mueller, U; Foerstl, H; Illig, T; Kurz, A
Abstract:
Epidemiological studies identified a higher risk of developing Alzheimer's disease (AD) among subjects with elevated cholesterol levels. This association may be caused by a modulation of the amyloid precursor protein (APP) processing in response to the cellular cholesterol content. High cholesterol levels may favor the amyloidogenic pathway by inhibition of the alpha-secretase probably leading to elevated beta-Amyloid (Abeta) production. The identification of a linkage peak on chromosome 10q usi...     »
Zeitschriftentitel:
Neurobiol Aging
Jahr:
2004
Band / Volume:
25
Heft / Issue:
10
Seitenangaben Beitrag:
1305-8
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.neurobiolaging.2004.01.001
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15465627
Print-ISSN:
0197-4580
TUM Einrichtung:
Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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