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Title:

Prion protein codon 129 polymorphism and risk of Alzheimer disease.

Document type:
Journal Article; Article
Author(s):
Riemenschneider, M; Klopp, N; Xiang, W; Wagenpfeil, S; Vollmert, C; Müller, U; Förstl, H; Illig, T; Kretzschmar, H; Kurz, A
Abstract:
The authors investigated the PRNP Met129Val polymorphism in 1,393 subjects including 482 patients with Alzheimer disease (AD) and two independent control groups. In patients, PRNP Met homozygosity conferred increasing risk with decreasing age at onset (onset: 61 to 70 years, n = 151, p = 0.02, odds ratio [OR] = 1.72, 95% CI = 1.2 to 2.53; onset: < or =60 years, n = 138, p = 0.013, OR = 1.92, 95% CI = 1.31 to 2.87), whereas no association was obtained in patients with onset at older than 70 years. The results suggest involvement of the prion protein in the pathogenesis of early-onset AD.
Journal title abbreviation:
Neurology
Year:
2004
Journal volume:
63
Journal issue:
2
Pages contribution:
364-6
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15277640
Print-ISSN:
0028-3878
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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