Prion protein codon 129 polymorphism and risk of Alzheimer disease.

Titel:: Prion protein codon 129 polymorphism and risk of Alzheimer disease.
Dokumenttyp:: Journal Article; Article
Autor(en):: Riemenschneider, M; Klopp, N; Xiang, W; Wagenpfeil, S; Vollmert, C; Müller, U; Förstl, H; Illig, T; Kretzschmar, H; Kurz, A
Abstract:: The authors investigated the PRNP Met129Val polymorphism in 1,393 subjects including 482 patients with Alzheimer disease (AD) and two independent control groups. In patients, PRNP Met homozygosity conferred increasing risk with decreasing age at onset (onset: 61 to 70 years, n = 151, p = 0.02, odds ratio [OR] = 1.72, 95% CI = 1.2 to 2.53; onset: < or =60 years, n = 138, p = 0.013, OR = 1.92, 95% CI = 1.31 to 2.87), whereas no association was obtained in patients with onset at older than 70 years. The results suggest involvement of the prion protein in the pathogenesis of early-onset AD.
Zeitschriftentitel:: Neurology
Jahr:: 2004
Band / Volume:: 63
Heft / Issue:: 2
Seitenangaben Beitrag:: 364-6
Sprache:: eng
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/15277640
Print-ISSN:: 0028-3878
TUM Einrichtung:: Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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