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Titel:

The N-methyl-D-aspartate antagonist memantine retards progression of Huntington's disease.

Dokumenttyp:
Clinical Trial; Journal Article; Multicenter Study; Article
Autor(en):
Beister, A; Kraus, P; Kuhn, W; Dose, M; Weindl, A; Gerlach, M
Abstract:
According to the excitotoxicity hypothesis, neurotoxicity due to glutamate is regarded as potential factor in the progredient neurodegeneration of Huntington's disease (HD). Memantine, as a glutamate receptor antagonist, should counteract this mechanism. Its effectiveness (up to 30 mg/day) with regard to retardation of progression was thus examined in 27 HD patients in a two year, open and multicentre trial. The results suggest that memantine treatment of HD may be useful in terms of retardation...     »
Zeitschriftentitel:
J Neural Transm Suppl
Jahr:
2004
Heft / Issue:
68
Seitenangaben Beitrag:
117-22
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15354397
Print-ISSN:
0303-6995
TUM Einrichtung:
Neurologische Klinik und Poliklinik
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