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Title:

Quantification of [18F]diprenorphine kinetics in the human brain with compartmental and non-compartmental modeling approaches.

Document type:
Journal Article; Article
Author(s):
Spilker, ME; Sprenger, T; Valet, M; Henriksen, G; Wagner, K; Wester, HJ; Toelle, TR; Boecker, H
Abstract:
6-O-(2-[(18)F]fluoroethyl)-6-O-desmethyldiprenorphine ([(18)F]FDPN) is a nonselective opiate ligand that binds to postsynaptic micro, kappa and delta opiate receptors. Due to the longer half-life of F-18, compared to C-11, labeling DPN with F-18 allows for alternative experimental protocols and potentially the evaluation of endogenous opioid release. The applicability of this compound to assorted experimental protocols motivated the evaluation of [(18)F]FDPN kinetics with compartmental and non-c...     »
Journal title abbreviation:
Neuroimage
Year:
2004
Journal volume:
22
Journal issue:
4
Pages contribution:
1523-33
Language:
eng
Fulltext / DOI:
doi:10.1016/j.neuroimage.2004.04.009
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15275909
Print-ISSN:
1053-8119
TUM Institution:
Klinik für Anästhesiologie (DHM); Klinik und Poliklinik für Nuklearmedizin; Neurologische Klinik und Poliklinik
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