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Title:

Isoflurane reduces glutamatergic transmission in neurons in the spinal cord superficial dorsal horn: evidence for a presynaptic site of an analgesic action.

Document type:
Journal Article
Author(s):
Haseneder, R; Kurz, J; Dodt, HU; Kochs, E; Zieglgänsberger, W; Scheller, M; Rammes, G; Hapfelmeier, G
Abstract:
The minimum alveolar concentration (MAC) of a volatile anesthetic defines anesthetic potency in terms of a suppressed motor response to a noxious stimulus. Therefore, the MAC of an anesthetic might in part reflect depression of motor neuron excitability. In the present study we evaluated the effect of isoflurane (ISO) on neurons in the substantia gelatinosa driven synaptically by putative nociceptive inputs in an in vitro spinal cord preparation of the rat. Whole-cell patch-clamp recordings were...     »
Journal title abbreviation:
Anesth Analg
Year:
2004
Journal volume:
98
Journal issue:
6
Pages contribution:
1718-23, table of content
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15155334
Print-ISSN:
0003-2999
TUM Institution:
Klinik für Anästhesiologie (DHM)
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