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Title:

Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner.

Document type:
Journal Article; Article
Author(s):
Rutz, M; Metzger, J; Gellert, T; Luppa, P; Lipford, GB; Wagner, H; Bauer, S
Abstract:
Toll-like receptors (TLR) recognize bacterial and viral components, but direct interaction of receptor and ligand is unclear. Here, we demonstrate that TLR9 binds directly and sequence-specifically to single-stranded unmethylated CpG-DNA containing a phosphodiester backbone. TLR9-CpG-DNA interaction occurs at the acidic pH (6.5-5.0) found in endosomes and lysosomes. By sequence comparison we identified a potential CpG-DNA binding domain homologous to that described for methyl-CpG-DNA binding pro...     »
Journal title abbreviation:
Eur J Immunol
Year:
2004
Journal volume:
34
Journal issue:
9
Pages contribution:
2541-50
Language:
eng
Fulltext / DOI:
doi:10.1002/eji.200425218
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15307186
Print-ISSN:
0014-2980
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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