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Title:

Detection of IKKbeta-IKKgamma subcomplexes in monocytic cells and characterization of associated signaling.

Document type:
Journal Article; Article
Author(s):
Quirling, M; Page, S; Jilg, N; Plenagl, K; Peus, D; Grubmüller, C; Weingärtner, M; Fischer, C; Neumeier, D; Brand, K
Abstract:
The IkappaB kinase (IKK) complex is one major step in the regulation of the NF-kappaB/Rel system that is involved in inflammatory and immune responses as well as in proliferation and apoptosis. At present it is not clear whether besides the "classical" IKKalpha-IKKbeta-IKKgamma configuration additional complexes exist in vivo that solely contain IKKbeta and IKKgamma (without IKKalpha). In the current study we were able to demonstrate in monocytic cells that endogenous complexes, which only inclu...     »
Journal title abbreviation:
J Biol Chem
Year:
2004
Journal volume:
279
Journal issue:
36
Pages contribution:
37452-60
Language:
eng
Fulltext / DOI:
doi:10.1074/jbc.M312119200
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15226300
Print-ISSN:
0021-9258
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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