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Titel:

Detection of IKKbeta-IKKgamma subcomplexes in monocytic cells and characterization of associated signaling.

Dokumenttyp:
Journal Article; Article
Autor(en):
Quirling, M; Page, S; Jilg, N; Plenagl, K; Peus, D; Grubmüller, C; Weingärtner, M; Fischer, C; Neumeier, D; Brand, K
Abstract:
The IkappaB kinase (IKK) complex is one major step in the regulation of the NF-kappaB/Rel system that is involved in inflammatory and immune responses as well as in proliferation and apoptosis. At present it is not clear whether besides the "classical" IKKalpha-IKKbeta-IKKgamma configuration additional complexes exist in vivo that solely contain IKKbeta and IKKgamma (without IKKalpha). In the current study we were able to demonstrate in monocytic cells that endogenous complexes, which only inclu...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
2004
Band / Volume:
279
Heft / Issue:
36
Seitenangaben Beitrag:
37452-60
Sprache:
eng
Volltext / DOI:
doi:10.1074/jbc.M312119200
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15226300
Print-ISSN:
0021-9258
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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