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Title:

Systemic inflammation leads to resistance to atracurium without increasing membrane expression of acetylcholine receptors.

Document type:
Journal Article; Article
Author(s):
Fink, H; Luppa, P; Mayer, B; Rosenbrock, H; Metzger, J; Martyn, JA; Blobner, M
Abstract:
BACKGROUND: Systemic inflammation may be associated with resistance to nondepolarizing neuromuscular blocking drugs, the mechanisms of which are, however, uncharacterized. The authors therefore investigated the pharmacodynamics of atracurium and its relation to the expression of nicotinic acetylcholine receptors and alpha1 -acid glycoprotein in a rat model of systemic inflammation. METHODS: To induce a systemic inflammation, male CD rats received 56 mg/kg corynebacterium parvum intravenously. On...     »
Journal title abbreviation:
Anesthesiology
Year:
2003
Journal volume:
98
Journal issue:
1
Pages contribution:
82-8
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12502983
Print-ISSN:
0003-3022
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; Klinik für Anästhesiologie (DHM)
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