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Title:

Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor.

Document type:
Journal Article
Author(s):
Eisensamer, B; Rammes, G; Gimpl, G; Shapa, M; Ferrari, U; Hapfelmeier, G; Bondy, B; Parsons, C; Gilling, K; Zieglgänsberger, W; Holsboer, F; Rupprecht, R
Abstract:
Antidepressants are commonly supposed to enhance serotonergic and/or noradrenergic neurotransmission by inhibition of neurotransmitter reuptake through binding to the respective neurotransmitter transporters or through inhibition of the monoamine oxidase. Using the concentration-clamp technique and measurements of intracellular Ca2+, we demonstrate that different classes of antidepressants act as functional antagonists at the human 5-HT3A receptor stably expressed in HEK 293 cells and at endogen...     »
Journal title abbreviation:
Mol Psychiatry
Year:
2003
Journal volume:
8
Journal issue:
12
Pages contribution:
994-1007
Language:
eng
Fulltext / DOI:
doi:10.1038/sj.mp.4001314
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/14647397
Print-ISSN:
1359-4184
TUM Institution:
Klinik für Anästhesiologie (DHM)
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