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Title:

Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells.

Document type:
Journal Article; Article
Author(s):
Muschaweckh, Andreas; Buchholz, Veit R; Fellenzer, Anne; Hessel, Christian; König, Paul-Albert; Tao, Sha; Tao, Ronny; Heikenwälder, Mathias; Busch, Dirk H; Korn, Thomas; Kastenmüller, Wolfgang; Drexler, Ingo; Gasteiger, Georg
Abstract:
Tissue-resident memory CD8(+) T cells (TRM) constitute a major component of the immune-surveillance system in nonlymphoid organs. Local, noncognate factors are both necessary and sufficient to support the programming of TRM cell fate in tissue-infiltrating T cells. Recent evidence suggests that TCR signals received in infected nonlymphoid tissues additionally contribute to TRM cell formation. Here, we asked how antigen-dependent pathways influence the generation of skin-resident memory T cells t...     »
Journal title abbreviation:
J Exp Med
Year:
2016
Journal volume:
213
Journal issue:
13
Pages contribution:
3075-3086
Language:
eng
Fulltext / DOI:
doi:10.1084/jem.20160888
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27899444
Print-ISSN:
0022-1007
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Molekulare Immunologie (Prof. Knolle)
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