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Titel:

Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection.

Dokumenttyp:
Journal Article; Article
Autor(en):
Steinbach, Karin; Vincenti, Ilena; Kreutzfeldt, Mario; Page, Nicolas; Muschaweckh, Andreas; Wagner, Ingrid; Drexler, Ingo; Pinschewer, Daniel; Korn, Thomas; Merkler, Doron
Abstract:
Tissue-resident memory T cells (TRM) persist at sites of prior infection and have been shown to enhance pathogen clearance by recruiting circulating immune cells and providing bystander activation. Here, we characterize the functioning of brain-resident memory T cells (bTRM) in an animal model of viral infection. bTRM were subject to spontaneous homeostatic proliferation and were largely refractory to systemic immune cell depletion. After viral reinfection in mice, bTRM rapidly acquired cytotoxi...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2016
Band / Volume:
213
Heft / Issue:
8
Seitenangaben Beitrag:
1571-87
Sprache:
eng
Volltext / DOI:
doi:10.1084/jem.20151916
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27377586
Print-ISSN:
0022-1007
TUM Einrichtung:
Molekulare Immunologie (Prof. Knolle)
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