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Title:

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Carambia, Antonella; Freund, Barbara; Schwinge, Dorothee; Bruns, Oliver T; Salmen, Sunhild C; Ittrich, Harald; Reimer, Rudolph; Heine, Markus; Huber, Samuel; Waurisch, Christian; Eychmüller, Alexander; Wraith, David C; Korn, Thomas; Nielsen, Peter; Weller, Horst; Schramm, Christoph; Lüth, Stefan; Lohse, Ansgar W; Heeren, Joerg; Herkel, Johannes
Abstract:
It is well-known that the liver can induce immune tolerance, yet this knowledge could, thus far, not be translated into effective treatments for autoimmune diseases. We have previously shown that liver sinusoidal endothelial cells (LSECs) could substantially contribute to hepatic tolerance through their ability to induce CD4+ Foxp3+ regulatory T cells (Tregs). Here, we explored whether the Treg-inducing potential of LSECs could be harnessed for the treatment of autoimmune disease.We engineered a...     »
Journal title abbreviation:
J Hepatol
Year:
2015
Journal volume:
62
Journal issue:
6
Pages contribution:
1349-56
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jhep.2015.01.006
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25617499
Print-ISSN:
0168-8278
TUM Institution:
Molekulare Immunologie (Prof. Knolle)
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