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Title:

The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) - a potential novel target in atherothrombosis prevention?

Document type:
Journal Article; Review
Author(s):
Joghetaei, Nader; Stein, Andreas; Byrne, Robert A; Schulz, Christian; King, Lamin; May, Andreas E; Schmidt, Roland
Abstract:
The immunoglobulin superfamily member EMMPRIN (CD147) plays an important role in a number of organ systems, including the cardiovascular system. Here we review the contemporary understanding of EMMPRIN and EMMPRIN-associated sequelae in the course of atherosclerosis. A significant body of data documents the pivotal role of EMMPRIN in the complex processes of atherogenesis, atheroprogression, and acute atherosclerothrombosis, a role that goes beyond that of a mere marker of inflammation.
Journal title abbreviation:
Thromb Res
Year:
2013
Journal volume:
131
Journal issue:
6
Pages contribution:
474-80
Language:
eng
Fulltext / DOI:
doi:10.1016/j.thromres.2013.04.017
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23669100
Print-ISSN:
0049-3848
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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