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Title:

Functional comparison of induced pluripotent stem cell- and blood-derived GPIIbIIIa deficient platelets.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Orban, Mathias; Goedel, Alexander; Haas, Jessica; Sandrock-Lang, Kirstin; Gärtner, Florian; Jung, Christian Billy; Zieger, Barbara; Parrotta, Elvira; Kurnik, Karin; Sinnecker, Daniel; Wanner, Gerhard; Laugwitz, Karl-Ludwig; Massberg, Steffen; Moretti, Alessandra
Abstract:
Human induced pluripotent stem cells (hiPSCs) represent a versatile tool to model genetic diseases and are a potential source for cell transfusion therapies. However, it remains elusive to which extent patient-specific hiPSC-derived cells functionally resemble their native counterparts. Here, we generated a hiPSC model of the primary platelet disease Glanzmann thrombasthenia (GT), characterized by dysfunction of the integrin receptor GPIIbIIIa, and compared side-by-side healthy and diseased hiPS...     »
Journal title abbreviation:
PLoS ONE
Year:
2015
Journal volume:
10
Journal issue:
1
Pages contribution:
e0115978
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0115978
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25607928
Print-ISSN:
1932-6203
TUM Institution:
Arbeitsgruppe Tissue Engineering und Regenerative Medizin; I. Medizinische Klinik und Poliklinik (Kardiologie)
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