Benutzer: Gast  Login
Titel:

Direct nkx2-5 transcriptional repression of isl1 controls cardiomyocyte subtype identity.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Dorn, Tatjana; Goedel, Alexander; Lam, Jason T; Haas, Jessica; Tian, Qinghai; Herrmann, Franziska; Bundschu, Karin; Dobreva, Gergana; Schiemann, Matthias; Dirschinger, Ralf; Guo, Yanchun; Kühl, Susanne J; Sinnecker, Daniel; Lipp, Peter; Laugwitz, Karl-Ludwig; Kühl, Michael; Moretti, Alessandra
Abstract:
During cardiogenesis, most myocytes arise from cardiac progenitors expressing the transcription factors Isl1 and Nkx2-5. Here, we show that a direct repression of Isl1 by Nkx2-5 is necessary for proper development of the ventricular myocardial lineage. Overexpression of Nkx2-5 in mouse embryonic stem cells (ESCs) delayed specification of cardiac progenitors and inhibited expression of Isl1 and its downstream targets in Isl1(+) precursors. Embryos deficient for Nkx2-5 in the Isl1(+) lineage faile...     »
Zeitschriftentitel:
Stem Cells
Jahr:
2015
Band / Volume:
33
Heft / Issue:
4
Seitenangaben Beitrag:
1113-29
Sprache:
eng
Volltext / DOI:
doi:10.1002/stem.1923
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25524439
Print-ISSN:
1066-5099
TUM Einrichtung:
Arbeitsgruppe Tissue Engineering und Regenerative Medizin; I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
 BibTeX