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Titel:

Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis.

Dokumenttyp:
journal article
Autor(en):
Interleukin 1 Genetics Consortium; Freitag, Daniel F; Butterworth, Adam S; Willeit, Peter; Howson, Joanna M M; Burgess, Stephen; Kaptoge, Stephen; Young, Robin; Ho, Weang Kee; Wood, Angela M; Sweeting, Michael; Spackman, Sarah; Staley, James R; Ramond, Anna; Harshfield, Eric; Nielsen, Sune F; Grande, Peer; Lange, Leslie A; Bown, Matthew J; Jones, Gregory T; Scott, Robert A; Bevan, Steve; Porcu, Eleonora; Thorleifsson, Gudmar; Zeng, Lingyao; Kessler, Thorsten; Do, Ron; Nikpay, Majid; Zhang, Weihu...     »
Abstract:
To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of inflammation.We created a genetic score combining the effects of alleles of two common variants (rs6743376 and rs1542176) that are located upstream of IL1RN, the gene encoding the IL-1 receptor antagonist (IL-1Ra; an endogenous inhibitor of both IL-1? and IL-1?); both alleles increase soluble I...     »
Zeitschriftentitel:
Lancet Diabetes Endocrinol
Jahr:
2015
Band / Volume:
3
Heft / Issue:
4
Seitenangaben Beitrag:
243-53
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25726324
Print-ISSN:
2213-8587
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen
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