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Title:

The level of hepatic ABCC6 expression determines the severity of calcification after cardiac injury.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Brampton, Christopher; Aherrahrou, Zouhair; Chen, Li-Hsieh; Martin, Ludovic; Bergen, Arthur A B; Gorgels, Theo G M F; Erdmann, Jeannette; Erdfdi, Jeannette; Schunkert, Heribert; Szabó, Zalán; Váradi, András; Le Saux, Olivier
Abstract:
Because vascular or cardiac mineralization is inversely correlated with morbidity and long-term survival, we investigated the role of ABCC6 in the calcification response to cardiac injury in mice. By using two models of infarction, nonischemic cryoinjury and the pathologically relevant coronary artery ligation, we confirmed a large propensity to acute cardiac mineralization in Abcc6-/- mice. Furthermore, when the expression of ABCC6 was reduced to approximately 38% of wild-type levels in Abcc6+/...     »
Journal title abbreviation:
Am J Pathol
Year:
2014
Journal volume:
184
Journal issue:
1
Pages contribution:
159-70
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24479134
Print-ISSN:
0002-9440
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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