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Titel:

The level of hepatic ABCC6 expression determines the severity of calcification after cardiac injury.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Brampton, Christopher; Aherrahrou, Zouhair; Chen, Li-Hsieh; Martin, Ludovic; Bergen, Arthur A B; Gorgels, Theo G M F; Erdmann, Jeannette; Erdfdi, Jeannette; Schunkert, Heribert; Szabó, Zalán; Váradi, András; Le Saux, Olivier
Abstract:
Because vascular or cardiac mineralization is inversely correlated with morbidity and long-term survival, we investigated the role of ABCC6 in the calcification response to cardiac injury in mice. By using two models of infarction, nonischemic cryoinjury and the pathologically relevant coronary artery ligation, we confirmed a large propensity to acute cardiac mineralization in Abcc6-/- mice. Furthermore, when the expression of ABCC6 was reduced to approximately 38% of wild-type levels in Abcc6+/...     »
Zeitschriftentitel:
Am J Pathol
Jahr:
2014
Band / Volume:
184
Heft / Issue:
1
Seitenangaben Beitrag:
159-70
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24479134
Print-ISSN:
0002-9440
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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