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Title:

Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.

Document type:
Journal Article; Meta-Analysis
Author(s):
Mäkinen, Ville-Petteri; Civelek, Mete; Meng, Qingying; Zhang, Bin; Zhu, Jun; Levian, Candace; Huan, Tianxiao; Segrè, Ayellet V; Ghosh, Sujoy; Vivar, Juan; Nikpay, Majid; Stewart, Alexandre F R; Nelson, Christopher P; Willenborg, Christina; Erdmann, Jeanette; Blakenberg, Stefan; O'Donnell, Christopher J; März, Winfried; Laaksonen, Reijo; Epstein, Stephen E; Kathiresan, Sekar; Shah, Svati H; Hazen, Stanley L; Reilly, Muredach P; Lusis, Aldons J; Samani, Nilesh J; Schunkert, Heribert; Quertermous,...     »
Abstract:
The majority of the heritability of coronary artery disease (CAD) remains unexplained, despite recent successes of genome-wide association studies (GWAS) in identifying novel susceptibility loci. Integrating functional genomic data from a variety of sources with a large-scale meta-analysis of CAD GWAS may facilitate the identification of novel biological processes and genes involved in CAD, as well as clarify the causal relationships of established processes. Towards this end, we integrated 14 G...     »
Journal title abbreviation:
PLoS Genet
Year:
2014
Journal volume:
10
Journal issue:
7
Pages contribution:
e1004502
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pgen.1004502
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25033284
Print-ISSN:
1553-7390
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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