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Titel:

Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.

Dokumenttyp:
Journal Article; Meta-Analysis
Autor(en):
Mäkinen, Ville-Petteri; Civelek, Mete; Meng, Qingying; Zhang, Bin; Zhu, Jun; Levian, Candace; Huan, Tianxiao; Segrè, Ayellet V; Ghosh, Sujoy; Vivar, Juan; Nikpay, Majid; Stewart, Alexandre F R; Nelson, Christopher P; Willenborg, Christina; Erdmann, Jeanette; Blakenberg, Stefan; O'Donnell, Christopher J; März, Winfried; Laaksonen, Reijo; Epstein, Stephen E; Kathiresan, Sekar; Shah, Svati H; Hazen, Stanley L; Reilly, Muredach P; Lusis, Aldons J; Samani, Nilesh J; Schunkert, Heribert; Quertermous,...     »
Abstract:
The majority of the heritability of coronary artery disease (CAD) remains unexplained, despite recent successes of genome-wide association studies (GWAS) in identifying novel susceptibility loci. Integrating functional genomic data from a variety of sources with a large-scale meta-analysis of CAD GWAS may facilitate the identification of novel biological processes and genes involved in CAD, as well as clarify the causal relationships of established processes. Towards this end, we integrated 14 G...     »
Zeitschriftentitel:
PLoS Genet
Jahr:
2014
Band / Volume:
10
Heft / Issue:
7
Seitenangaben Beitrag:
e1004502
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pgen.1004502
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25033284
Print-ISSN:
1553-7390
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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