The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) - a potential novel target in atherothrombosis prevention?

Titel:: The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) - a potential novel target in atherothrombosis prevention?
Dokumenttyp:: Journal Article; Review
Autor(en):: Joghetaei, Nader; Stein, Andreas; Byrne, Robert A; Schulz, Christian; King, Lamin; May, Andreas E; Schmidt, Roland
Abstract:: The immunoglobulin superfamily member EMMPRIN (CD147) plays an important role in a number of organ systems, including the cardiovascular system. Here we review the contemporary understanding of EMMPRIN and EMMPRIN-associated sequelae in the course of atherosclerosis. A significant body of data documents the pivotal role of EMMPRIN in the complex processes of atherogenesis, atheroprogression, and acute atherosclerothrombosis, a role that goes beyond that of a mere marker of inflammation.
Zeitschriftentitel:: Thromb Res
Jahr:: 2013
Band / Volume:: 131
Heft / Issue:: 6
Seitenangaben Beitrag:: 474-80
Sprache:: eng
Volltext / DOI:: doi:10.1016/j.thromres.2013.04.017
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/23669100
Print-ISSN:: 0049-3848
TUM Einrichtung:: Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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