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Titel:

Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Article
Autor(en):
Tang, Wenbo; Kowgier, Matthew; Loth, Daan W; Soler Artigas, Maria; Joubert, Bonnie R; Hodge, Emily; Gharib, Sina A; Smith, Albert V; Ruczinski, Ingo; Gudnason, Vilmundur; Mathias, Rasika A; Harris, Tamara B; Hansel, Nadia N; Launer, Lenore J; Barnes, Kathleen C; Hansen, Joyanna G; Albrecht, Eva; Aldrich, Melinda C; Allerhand, Michael; Barr, R Graham; Brusselle, Guy G; Couper, David J; Curjuric, Ivan; Davies, Gail; Deary, Ian J; Dupuis, Josée; Fall, Tove; Foy, Millennia; Franceschini, Nora; Gao,...     »
Abstract:
Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function.We performed GWAS of the rate of change in forced expiratory volume in the first second (FEV1) in 14 longitudinal, population-based cohort studies comprising 27,249 adults of European ancestry using linear mixed effects model and combined cohort-specific results using fixed effect meta-analysis to identify n...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2014
Band / Volume:
9
Heft / Issue:
7
Seitenangaben Beitrag:
e100776
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0100776
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24983941
Print-ISSN:
1932-6203
TUM Einrichtung:
Lehrstuhl für Allgemeinmedizin (Prof. Schneider) (keine SAP-Zuordnung!)
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