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Title:

Unlocking the promise of mRNA therapeutics.

Document type:
Journal Article; Review; Research Support, Non-U.S. Gov't
Author(s):
Rohner, Eduarde; Yang, Ran; Foo, Kylie S; Goedel, Alexander; Chien, Kenneth R
Abstract:
The extraordinary success of mRNA vaccines against coronavirus disease 2019 (COVID-19) has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical trials of mRNA therapeutics include studies of paracrine vascular endothelial growth factor (VEGF) mRNA for heart failure and of CRISPR-Cas9 mRNA for a congenital liver-specific storage disease. However, a series of challenges remains to be addressed before mRNA can be established as a general therapeutic modality with b...     »
Journal title abbreviation:
Nat Biotechnol
Year:
2022
Journal volume:
40
Journal issue:
11
Pages contribution:
1586-1600
Fulltext / DOI:
doi:10.1038/s41587-022-01491-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36329321
Print-ISSN:
1087-0156
TUM Institution:
Professur für Regenerative Medizin bei Kardiovaskulären Erkrankungen (Prof. Moretti)
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