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Titel:

Identification of Restless Legs Syndrome Genes by Mutational Load Analysis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Tilch, Erik; Schormair, Barbara; Zhao, Chen; Salminen, Aaro V; Antic Nikolic, Ana; Holzknecht, Evi; Högl, Birgit; Poewe, Werner; Bachmann, Cornelius G; Paulus, Walter; Trenkwalder, Claudia; Oertel, Wolfgang H; Hornyak, Magdolna; Fietze, Ingo; Berger, Klaus; Lichtner, Peter; Gieger, Christian; Peters, Annette; Müller-Myhsok, Bertram; Hoischen, Alexander; Winkelmann, Juliane; Oexle, Konrad
Abstract:
OBJECTIVE: Restless legs syndrome is a frequent neurological disorder with substantial burden on individual well-being and public health. Genetic risk loci have been identified, but the causatives genes at these loci are largely unknown, so that functional investigation and clinical translation of molecular research data are still inhibited. To identify putatively causative genes, we searched for highly significant mutational burden in candidate genes. METHODS: We analyzed 84 candidate genes in...     »
Zeitschriftentitel:
Ann Neurol
Jahr:
2020
Band / Volume:
87
Heft / Issue:
2
Seitenangaben Beitrag:
184-193
Volltext / DOI:
doi:10.1002/ana.25658
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31788832
Print-ISSN:
0364-5134
TUM Einrichtung:
1452; 656; Lehrstuhl für Neurogenetik (Prof. Winkelmann)
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