Is parental consanguinity associated with reduced ovarian reserve?

Seher, Tanja; Thiering, Elisabeth; Al Azemi, Majdah; Heinrich, Joachim; Schmidt-Weber, Carsten B; Kivlahan, Coleen; Gutermuth, Jan; Fatemi, Human M

doi:10.1016/j.rbmo.2015.06.003

2015

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Title:: Is parental consanguinity associated with reduced ovarian reserve?
Document type:: Journal Article
Author(s):: Seher, Tanja; Thiering, Elisabeth; Al Azemi, Majdah; Heinrich, Joachim; Schmidt-Weber, Carsten B; Kivlahan, Coleen; Gutermuth, Jan; Fatemi, Human M
Abstract:: This observational study assessed whether women descending from consanguineous unions have reduced ovarian reserve compared with daughters of non-consanguine couples. Two hundred and ninety-one women (<=39 years) were treated in a tertiary care centre in Kuwait. Women underwent a complete anamnesis, including an evaluation of the possible presence of parental consanguinity, transvaginal ultrasound on day 2/3 of the cycle to obtain the antral follicle count (AFC), determination of serum concentrations of FSH, LH, oestradiol and in case of low ovarian reserve (AFC < 9) anti-Müllerian hormone (AMH). The median AFC of non-consanguineous daughters was 11, while daughters from consanguineous parents displayed a significantly lower median AFC (7; P < 0?0001). FSH was slightly higher in the consanguineous patients, while LH and oestradiol concentrations did not vary between groups. In total, 29.9% of consanguineous patients had an AFC >= 9, compared with 63.9% of non-consanguineous patients. Consanguineous patients did not exhibit an age-dependent AFC-decline and displayed reduced AFC and AMH concentrations. The multivariate analysis revealed female consanguinity, as well as surgical history in non-consanguineous women, as strong positive predictors of low ovarian reserve. Parental consanguinity is strongly associated with reduced ovarian reserve. Future studies should evaluate a possible association between parental consanguinity and infertility.
Journal title abbreviation:: Reprod Biomed Online
Year:: 2015
Journal volume:: 31
Journal issue:: 3
Pages contribution:: 427-33
Language:: eng
Fulltext / DOI:: doi:10.1016/j.rbmo.2015.06.003
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/26206281
Print-ISSN:: 1472-6483
TUM Institution:: Molekulare Allergologie (Prof. Schmidt-Weber)
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