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Titel:

Parasite Proximity Drives the Expansion of Regulatory T Cells in Peyer's Patches following Intestinal Helminth Infection.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Mosconi, Ilaria; Dubey, Lalit Kumar; Volpe, Beatrice; Esser-von Bieren, Julia; Zaiss, Mario M; Lebon, Luc; Massacand, Joanna C; Harris, Nicola L
Abstract:
Helminth infections are typically chronic in nature; however, the exact molecular mechanisms by which these parasites promote or thwart host immunity remain unclear. Worm expulsion requires the differentiation of CD4(+) T cells into Th2 cells, while regulatory T cells (Tregs) act to dampen the extent of the Th2 response. Priming of T cells requires drainage or capture of antigens within lymphoid tissues, and in the case of intestinal helminths, such sites include the mucosa-associated Peyer's p...     »
Zeitschriftentitel:
Infect Immun
Jahr:
2015
Band / Volume:
83
Heft / Issue:
9
Seitenangaben Beitrag:
3657-65
Sprache:
eng
Volltext / DOI:
doi:10.1128/IAI.00266-15
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26150538
Print-ISSN:
0019-9567
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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