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Titel:

Reversal of CD8 T-Cell-Mediated Mucocutaneous Graft-Versus-Host-Like Disease by the JAK Inhibitor Tofacitinib.

Dokumenttyp:
Journal Article; Article
Autor(en):
Okiyama, Naoko; Furumoto, Yasuko; Villarroel, Vadim A; Linton, Jay T; Tsai, Wanxia L; Gutermuth, Jan; Ghoreschi, Kamran; Gadina, Massimo; O'Shea, John J; Katz, Stephen I
Abstract:
The utility of allogeneic hematopoietic stem cell transplantation is limited by graft-versus-host disease (GVHD), a significant cause of morbidity and mortality. Patients with GVHD exhibit cutaneous manifestations with histological features of interface dermatitis followed by scleroderma-like changes. JAK inhibitors represent a class of immunomodulatory drugs that inhibit signaling by multiple cytokines. Herein we report the effects of tofacitinib in a murine model of GVHD. Oral administration o...     »
Zeitschriftentitel:
J Invest Dermatol
Jahr:
2014
Band / Volume:
134
Heft / Issue:
4
Seitenangaben Beitrag:
992-1000
Sprache:
eng
Volltext / DOI:
doi:10.1038/jid.2013.476
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24213371
Print-ISSN:
0022-202X
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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