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Document type:
Journal Article; Article
Author(s):
Peters, LM; Demmel, S; Pusch, G; Buters, JT; Thormann, W; Zielinski, J; Leeb, T; Mevissen, M; Schmitz, A
Title:
Equine cytochrome P450 2B6--genomic identification, expression and functional characterization with ketamine.
Abstract:
Ketamine is an anesthetic and analgesic regularly used in veterinary patients. As ketamine is almost always administered in combination with other drugs, interactions between ketamine and other drugs bear the risk of either adverse effects or diminished efficacy. Since cytochrome P450 enzymes (CYPs) play a pivotal role in the phase I metabolism of the majority of all marketed drugs, drug-drug interactions often occur at the active site of these enzymes. CYPs have been thoroughly examined in huma...     »
Journal title abbreviation:
Toxicol Appl Pharmacol
Year:
2013
Journal volume:
266
Journal issue:
1
Pages contribution:
101-8
Language:
eng
Fulltext / DOI:
doi:10.1016/j.taap.2012.10.028
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23142468
Print-ISSN:
0041-008X
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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