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Titel:

Human T cell priming assay (hTCPA) for the identification of contact allergens based on naive T cells and DC--IFN-? and TNF-? readout.

Dokumenttyp:
Journal Article
Autor(en):
Richter, A; Schmucker, SS; Esser, PR; Traska, V; Weber, V; Dietz, L; Thierse, HJ; Pennino, D; Cavani, A; Martin, SF
Abstract:
Many small protein reactive organic and inorganic chemicals can cause allergic contact dermatitis, a T cell mediated inflammatory skin disease. In vitro alternatives to animal testing are needed for the identification of chemicals that pose such risks to human health. We here publish the standard operation procedure for a human T cell priming assay developed primarily for the identification of contact allergens within the integrated EU project Sens-it-iv. This multiparametric flow cytometry base...     »
Zeitschriftentitel:
Toxicol In Vitro
Jahr:
2013
Band / Volume:
27
Heft / Issue:
3
Seitenangaben Beitrag:
1180-5
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.tiv.2012.08.007
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22906571
Print-ISSN:
0887-2333
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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