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Titel:

Equine cytochrome P450 2B6--genomic identification, expression and functional characterization with ketamine.

Dokumenttyp:
Journal Article; Article
Autor(en):
Peters, LM; Demmel, S; Pusch, G; Buters, JT; Thormann, W; Zielinski, J; Leeb, T; Mevissen, M; Schmitz, A
Abstract:
Ketamine is an anesthetic and analgesic regularly used in veterinary patients. As ketamine is almost always administered in combination with other drugs, interactions between ketamine and other drugs bear the risk of either adverse effects or diminished efficacy. Since cytochrome P450 enzymes (CYPs) play a pivotal role in the phase I metabolism of the majority of all marketed drugs, drug-drug interactions often occur at the active site of these enzymes. CYPs have been thoroughly examined in huma...     »
Zeitschriftentitel:
Toxicol Appl Pharmacol
Jahr:
2013
Band / Volume:
266
Heft / Issue:
1
Seitenangaben Beitrag:
101-8
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.taap.2012.10.028
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23142468
Print-ISSN:
0041-008X
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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