Benutzer: Gast  Login
Mehr Felder
Einfache Suche
Titel:

Human IL-31 is induced by IL-4 and promotes TH2-driven inflammation.

Dokumenttyp:
Journal Article
Autor(en):
Stott, B; Lavender, P; Lehmann, S; Pennino, D; Durham, S; Schmidt-Weber, CB
Abstract:
The pruritic cytokine IL-31 has been shown to be expressed by murine activated effector T Lymphocytes of a TH2 phenotype. Like IL-17 and IL-22, IL-31 is a tissue-signaling cytokine the receptor of which is mainly found on nonimmune cells. An overabundance of IL-31 has been shown in patients with atopic disorders, including dermatitis, as well as asthma, and therefore represents a promising drug target, although its regulation in the context of the human TH2 clusters is not yet known.We sought to...     »
Zeitschriftentitel:
J Allergy Clin Immunol
Jahr:
2013
Band / Volume:
132
Heft / Issue:
2
Seitenangaben Beitrag:
446-454.e5
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jaci.2013.03.050
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23694808
Print-ISSN:
0091-6749
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
 BibTeX