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Titel:

Donor assists acceptor binding and catalysis of human ?1,6-fucosyltransferase.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Kötzler, Miriam P; Blank, Simon; Bantleon, Frank I; Wienke, Martin; Spillner, Edzard; Meyer, Bernd
Abstract:
?1,6-Core-fucosyltransferase (FUT8) is a vital enzyme in mammalian physiological and pathophysiological processes such as tumorigenesis and progress of, among others, non-small cell lung cancer and colon carcinoma. It was also shown that therapeutic antibodies have a dramatically higher efficacy if the ?1,6-fucosyl residue is absent. However, specific and potent inhibitors for FUT8 and related enzymes are lacking. Hence, it is crucial to elucidate the structural basis of acceptor binding and the...     »
Zeitschriftentitel:
ACS Chem Biol
Jahr:
2013
Band / Volume:
8
Heft / Issue:
8
Seitenangaben Beitrag:
1830-40
Sprache:
eng
Volltext / DOI:
doi:10.1021/cb400140u
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23730796
Print-ISSN:
1554-8929
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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