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Title:

Lifestyle intervention in BRCA1/2 mutation carriers: study protocol for a prospective, randomized, controlled clinical feasibility trial (LIBRE-1 study).

Document type:
Journal Article
Author(s):
Kiechle, Marion; Engel, Christoph; Berling, Anika; Hebestreit, Katrin; Bischoff, Stephan; Dukatz, Ricarda; Gerber, Wolf-Dieter; Siniatchkin, Michael; Pfeifer, Katharina; Grill, Sabine; Yahiaoui-Doktor, Maryam; Kirsch, Ellen; Niederberger, Uwe; Marter, Nicole; Enders, Ute; Löffler, Markus; Meindl, Alfons; Rhiem, Kerstin; Schmutzler, Rita; Erickson, Nicole; Halle, Martin
Abstract:
Women with highly penetrant BRCA mutations have a 55-60% lifetime risk for breast cancer and a 16-59% lifetime risk for ovarian cancer. However, penetrance differs interindividually, indicating that environmental and behavioral factors may modify this risk. These include lifestyle factors such as physical activity status, dietary habits, and body weight. The modification of penetrance by changing lifestyle factors has not thus far been investigated in a randomized trial in BRCA mutation carriers...     »
Journal title abbreviation:
Pilot Feasibility Stud
Year:
2016
Journal volume:
2
Pages contribution:
74
Language:
eng
Fulltext / DOI:
doi:10.1186/s40814-016-0114-7
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28031860
Print-ISSN:
2055-5784
TUM Institution:
Poliklinik für Präventive und Rehabilitative Sportmedizin
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