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Title:

VEGF released by deferoxamine preconditioned mesenchymal stem cells seeded on collagen-GAG substrates enhances neovascularization.

Document type:
Journal Article; Article
Author(s):
Wahl, Elizabeth A; Schenck, Thilo L; Machens, Hans-Günther; Balmayor, Elizabeth R
Abstract:
Hypoxia preconditioning of mesenchymal stem cells (MSCs) has been shown to promote wound healing through HIF-1? stabilization. Preconditioned MSCs can be applied to three-dimensional biomaterials to further enhance the regenerative properties. While environmentally induced hypoxia has proven difficult in clinical settings, this study compares the wound healing capabilities of adipose derived (Ad) MSCs seeded on a collagen-glycosaminoglycan (GAG) dermal substrate exposed to either environmental h...     »
Journal title abbreviation:
Sci Rep
Year:
2016
Journal volume:
6
Pages contribution:
36879
Language:
eng
Fulltext / DOI:
doi:10.1038/srep36879
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27830734
Print-ISSN:
2045-2322
TUM Institution:
Klinik und Poliklinik für Unfallchirurgie; Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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