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Title:

Acute stimulation of mesenchymal stem cells with cigarette smoke extract affects their migration, differentiation, and paracrine potential.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Wahl, Elizabeth A; Schenck, Thilo L; Machens, Hans-Günther; Egaña, J Tomás
Abstract:
Mesenchymal stem cells (MSCs) are known to play a key role in tissue regeneration, while smoking cigarettes is described to impair it. This work focuses on the effect cigarette smoke extract (CSE) has on the migration, differentiation, and paracrine potential of human adipose derived MSCs (AdMSCs). To mimic native conditions in vitro, AdMSCs were cultured in either monolayer or three-dimensional pellet cultures. While constant exposure to high concentrations of CSE had lethal effects on AdMSCs,...     »
Journal title abbreviation:
Sci Rep
Year:
2016
Journal volume:
6
Pages contribution:
22957
Language:
eng
Fulltext / DOI:
doi:10.1038/srep22957
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26976359
Print-ISSN:
2045-2322
TUM Institution:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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