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Titel:

Acute stimulation of mesenchymal stem cells with cigarette smoke extract affects their migration, differentiation, and paracrine potential.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Wahl, Elizabeth A; Schenck, Thilo L; Machens, Hans-Günther; Egaña, J Tomás
Abstract:
Mesenchymal stem cells (MSCs) are known to play a key role in tissue regeneration, while smoking cigarettes is described to impair it. This work focuses on the effect cigarette smoke extract (CSE) has on the migration, differentiation, and paracrine potential of human adipose derived MSCs (AdMSCs). To mimic native conditions in vitro, AdMSCs were cultured in either monolayer or three-dimensional pellet cultures. While constant exposure to high concentrations of CSE had lethal effects on AdMSCs,...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2016
Band / Volume:
6
Seitenangaben Beitrag:
22957
Sprache:
eng
Volltext / DOI:
doi:10.1038/srep22957
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26976359
Print-ISSN:
2045-2322
TUM Einrichtung:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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