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Title:

The Fibrin Matrix Regulates Angiogenic Responses within the Hemostatic Microenvironment through Biochemical Control.

Document type:
Journal Article
Author(s):
Hadjipanayi, Ektoras; Kuhn, Peer-Hendrik; Moog, Philipp; Bauer, Anna-Theresa; Kuekrek, Haydar; Mirzoyan, Lilit; Hummel, Anja; Kirchhoff, Katharina; Salgin, Burak; Isenburg, Sarah; Dornseifer, Ulf; Ninkovic, Milomir; Machens, Hans-Günther; Schilling, Arndt F
Abstract:
Conceptually, premature initiation of post-wound angiogenesis could interfere with hemostasis, as it relies on fibrinolysis. The mechanisms facilitating orchestration of these events remain poorly understood, however, likely due to limitations in discerning the individual contribution of cells and extracellular matrix. Here, we designed an in vitro Hemostatic-Components-Model (HCM) to investigate the role of the fibrin matrix as protein factor-carrier, independent of its cell-scaffold function....     »
Journal title abbreviation:
PLoS ONE
Year:
2015
Journal volume:
10
Journal issue:
8
Pages contribution:
e0135618
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0135618
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26317771
Print-ISSN:
1932-6203
TUM Institution:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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