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Title:

Neuronal hyperactivity--A key defect in Alzheimer's disease?

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Busche, Marc Aurel; Konnerth, Arthur
Abstract:
Traditionally, the impairment of cognitive functions in Alzheimer's disease (AD) is thought to result from a reduction in neuronal and synaptic activities, and ultimately cell death. Here, we review recent in vivo evidence from mouse models and human patients indicating that, particularly in early stages of AD, neuronal circuits are hyperactive instead of hypoactive. Functional analyses at many levels, from single neurons to neuronal populations to large-scale networks, with a variety of electro...     »
Journal title abbreviation:
Bioessays
Year:
2015
Journal volume:
37
Journal issue:
6
Pages contribution:
624-32
Language:
eng
Fulltext / DOI:
doi:10.1002/bies.201500004
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25773221
Print-ISSN:
0265-9247
TUM Institution:
Institut für Neurowissenschaften; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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