Value of Early Postoperative FLAIR Volume Dynamic in Glioma with No or Minimal Enhancement.

Bette, Stefanie; Kaesmacher, Johannes; Huber, Thomas; Delbridge, Claire; Ringel, Florian; Boeckh-Behrens, Tobias; Meyer, Bernhard; Zimmer, Claus; Kirschke, Jan S; Gempt, Jens

doi:10.1016/j.wneu.2016.03.034

journal article

Title:: Value of Early Postoperative FLAIR Volume Dynamic in Glioma with No or Minimal Enhancement.
Document type:: Journal Article; Article
Author(s):: Bette, Stefanie; Kaesmacher, Johannes; Huber, Thomas; Delbridge, Claire; Ringel, Florian; Boeckh-Behrens, Tobias; Meyer, Bernhard; Zimmer, Claus; Kirschke, Jan S; Gempt, Jens
Abstract:: The evaluation of postoperative magnetic resonance imaging (MRI) in glioma with no or minimal enhancement is controversial because the evaluation of residual tumor volume can be biased. The purpose of this study was to clarify the value of early postoperative and 3-month MRI regarding its validity in predicting recurrent disease.For this retrospective, single-center study, overall fluid attenuated inversion recovery (FLAIR) volumes (early postoperative [<48 hours] and 3-month MRI including FLAIR and T1-weighted sequences with and without contrast agent) of 99 patients were assessed using manual segmentation. FLAIR volume dynamic over the first 3 months after surgery and its effect on disease recurrence were evaluated while considering histopathologic features.Overall FLAIR-hyperintense volume significantly decreased between early postoperative and 3-month follow-up MRIs (P < 0.001). Early FLAIR volume increase had a high positive predictive value for overall disease recurrence after resection (85.71% [95%-CI: 62.64-96.24]). Early FLAIR volume dynamic (P < 0.001), isocitrate dehydrogenase 1/2 status (P = 0.002), and preoperative Karnofsky Performance Status (P = 0.012) were observed as independent factors for progression-free survival in multivariate analysis.Early postoperative FLAIR volume assessment in gliomas with no or minimal enhancement is susceptible to a systematic overestimation of residual tumors. Nevertheless, early FLAIR volume dynamic is an independent factor for tumor recurrence that should be evaluated in order timely adapt surveillance and therapy regimens accordingly.
Journal title abbreviation:: World Neurosurg
Year:: 2016
Journal volume:: 91
Pages contribution:: 548-559.e1
Language:: eng
Fulltext / DOI:: doi:10.1016/j.wneu.2016.03.034
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/27004759
Print-ISSN:: 1878-8750
TUM Institution:: Fachgebiet Neuroradiologie (Prof. Zimmer); Institut für Allgemeine Pathologie und Pathologische Anatomie; Neurochirurgische Klinik und Poliklinik
BibTeX

Occurrences:

mediaTUM Gesamtbestand Hochschulbibliographie 2016 Fakultäten Medizin Institut für Radiologie

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Preclinical Medicine Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.)2016

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Neurochirurgie (Prof. Meyer)2016

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)Abteilung für Diagnostische und Interventionelle Neuroradiologie (Prof. Zimmer)Professur für Neuroradiologie (Prof. Zimmer)2016

mediaTUM Gesamtbestand Hochschulbibliographie 2016 Fakultäten Medizin Institut für Allgemeine Pathologie und Pathologische Anatomie