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Title:

Immunological and Translational Aspects of NK Cell-Based Antitumor Immunotherapies.

Document type:
Journal Article; Review
Author(s):
Shevtsov, Maxim; Multhoff, Gabriele
Abstract:
Natural killer (NK) cells play a pivotal role in the first line of defense against cancer. NK cells that are deficient in CD3 and a clonal T cell receptor (TCR) can be subdivided into two major subtypes, CD56(dim)CD16(+) cytotoxic and CD56(bright)CD16(-) immunoregulatory NK cells. Cytotoxic NK cells not only directly kill tumor cells without previous stimulation by cytotoxic effector molecules, such as perforin and granzymes or via death receptor interactions, but also act as regulatory cells fo...     »
Journal title abbreviation:
Front Immunol
Year:
2016
Journal volume:
7
Pages contribution:
492
Language:
eng
Fulltext / DOI:
doi:10.3389/fimmu.2016.00492
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27891129
Print-ISSN:
1664-3224
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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