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Titel:

Heat Shock Protein-Peptide and HSP-Based Immunotherapies for the Treatment of Cancer.

Dokumenttyp:
Journal Article; Review
Autor(en):
Shevtsov, Maxim; Multhoff, Gabriele
Abstract:
Intracellular residing heat shock proteins (HSPs) with a molecular weight of approximately 70 and 90 kDa function as molecular chaperones that assist folding/unfolding and transport of proteins across membranes and prevent protein aggregation after environmental stress. In contrast to normal cells, tumor cells have higher cytosolic heat shock protein 70 and Hsp90 levels, which contribute to tumor cell propagation, metastasis, and protection against apoptosis. In addition to their intracellular c...     »
Zeitschriftentitel:
Front Immunol
Jahr:
2016
Band / Volume:
7
Seitenangaben Beitrag:
171
Sprache:
eng
Volltext / DOI:
doi:10.3389/fimmu.2016.00171
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27199993
Print-ISSN:
1664-3224
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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