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Titel:

Targeted next-generation sequencing of locally advanced squamous cell carcinomas of the head and neck reveals druggable targets for improving adjuvant chemoradiation.

Dokumenttyp:
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Article
Autor(en):
Tinhofer, I; Budach, V; Saki, M; Konschak, R; Niehr, F; Jöhrens, K; Weichert, W; Linge, A; Lohaus, F; Krause, M; Neumann, K; Endris, V; Sak, A; Stuschke, M; Balermpas, P; Rödel, C; Avlar, M; Grosu, A L; Abdollahi, A; Debus, J; Belka, C; Pigorsch, S; Combs, S E; Mönnich, D; Zips, D; Baumann, M
Abstract:
Despite clear differences in clinical presentation and outcome, squamous cell carcinomas of the head and neck (SCCHN) arising from human papilloma virus (HPV) infection or heavy tobacco/alcohol consumption are treated equally. Next-generation sequencing is expected to reveal novel targets for more individualised treatment.Tumour specimens from 208 patients with locally advanced squamous cell carcinoma of the hypopharynx, oropharynx or oral cavity, all uniformly treated with adjuvant cisplatin-ba...     »
Zeitschriftentitel:
Eur J Cancer
Jahr:
2016
Band / Volume:
57
Seitenangaben Beitrag:
78-86
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.ejca.2016.01.003
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26896955
Print-ISSN:
0959-8049
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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