Benutzer: Gast  Login
Titel:

Immunological and Translational Aspects of NK Cell-Based Antitumor Immunotherapies.

Dokumenttyp:
Journal Article; Review
Autor(en):
Shevtsov, Maxim; Multhoff, Gabriele
Abstract:
Natural killer (NK) cells play a pivotal role in the first line of defense against cancer. NK cells that are deficient in CD3 and a clonal T cell receptor (TCR) can be subdivided into two major subtypes, CD56(dim)CD16(+) cytotoxic and CD56(bright)CD16(-) immunoregulatory NK cells. Cytotoxic NK cells not only directly kill tumor cells without previous stimulation by cytotoxic effector molecules, such as perforin and granzymes or via death receptor interactions, but also act as regulatory cells fo...     »
Zeitschriftentitel:
Front Immunol
Jahr:
2016
Band / Volume:
7
Seitenangaben Beitrag:
492
Sprache:
eng
Volltext / DOI:
doi:10.3389/fimmu.2016.00492
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27891129
Print-ISSN:
1664-3224
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
 BibTeX