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Titel:

Individualized versus standardized risk assessment in patients at high risk for adverse drug reactions (IDrug) - study protocol for a pragmatic randomized controlled trial.

Dokumenttyp:
Comparative Study; Journal Article; Multicenter Study; Pragmatic Clinical Trial; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Article
Autor(en):
Stingl, Julia Carolin; Kaumanns, Katharina Luise; Claus, Katrin; Lehmann, Marie-Louise; Kastenmüller, Kathrin; Bleckwenn, Markus; Hartmann, Gunther; Steffens, Michael; Wirtz, Dorothee; Leuchs, Ann-Kristin; Benda, Norbert; Meier, Florian; Schöffski, Oliver; Holdenrieder, Stefan; Coch, Christoph; Weckbecker, Klaus
Abstract:
Elderly patients are particularly vulnerable to adverse drug reactions, especially if they are affected by additional risk factors such as multimorbidity, polypharmacy, impaired renal function and intake of drugs with high risk potential. Apart from these clinical parameters, drug safety and efficacy can be influenced by pharmacogenetic factors. Evidence-based recommendations concerning drug-gene-combinations have been issued by international consortia and in drug labels. However, clinical benef...     »
Zeitschriftentitel:
BMC Fam Pract
Jahr:
2016
Band / Volume:
17
Seitenangaben Beitrag:
49
Sprache:
eng
Volltext / DOI:
doi:10.1186/s12875-016-0447-6
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27112273
Print-ISSN:
1471-2296
TUM Einrichtung:
Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!)
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