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Titel:

Effectiveness of antiepileptic therapy in patients with PCDH19 mutations.

Dokumenttyp:
Journal Article; Multicenter Study
Autor(en):
Lotte, Jan; Bast, Thomas; Borusiak, Peter; Coppola, Antonietta; Cross, J Helen; Dimova, Petia; Fogarasi, Andras; Graneß, Irene; Guerrini, Renzo; Hjalgrim, Helle; Keimer, Reinhard; Korff, Christian M; Kurlemann, Gerhard; Leiz, Steffen; Linder-Lucht, Michaela; Loddenkemper, Tobias; Makowski, Christine; Mühe, Christian; Nicolai, Joost; Nikanorova, Marina; Pellacani, Simona; Philip, Sunny; Ruf, Susanne; Sánchez Fernández, Iván; Schlachter, Kurt; Striano, Pasquale; Sukhudyan, Biayna; Valcheva, Deyana...     »
Abstract:
PCDH19 mutations cause epilepsy and mental retardation limited to females (EFMR) or Dravet-like syndromes. Especially in the first years of life, epilepsy is known to be highly pharmacoresistant. The aim of our study was to evaluate the effectiveness of antiepileptic therapy in patients with PCDH19 mutations.We report a retrospective multicenter study of antiepileptic therapy in 58 female patients with PCDH19 mutations and epilepsy aged 2-27 years (mean age 10.6 years).The most effective drugs a...     »
Zeitschriftentitel:
Seizure
Jahr:
2016
Band / Volume:
35
Seitenangaben Beitrag:
106-10
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.seizure.2016.01.006
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26820223
Print-ISSN:
1059-1311
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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