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Titel:

Targeting the EWS-FLI1 transcription factor in Ewing sarcoma.

Dokumenttyp:
Case Reports; Journal Article; Article
Autor(en):
Tancredi, R; Zambelli, A; DaPrada, G A; Fregoni, V; Pavesi, L; Riccardi, A; Burdach, S; Grohar, P J; D'Incalci, M
Abstract:
Preclinical data indicate there is strong synergism of action against Ewing sarcoma in sequential treatment with trabectedin followed by irinotecan and it appears to be related to a selective blockade of the transcription factor EWS-FLI1. This combination was evaluated in Ewing sarcoma patient who was progressing with standard therapies.Trabectedin was given as a 24-h iv infusion on day 1 at the dose of 1 mg/sqm, and irinotecan 75 mg/sqm on day 2 and then on days 2 and 4, every 3 weeks from the...     »
Zeitschriftentitel:
Cancer Chemother Pharmacol
Jahr:
2015
Band / Volume:
75
Heft / Issue:
6
Seitenangaben Beitrag:
1317-20
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00280-015-2726-7
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25809543
Print-ISSN:
0344-5704
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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