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Title:

Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Mikhed, Yuliya; Görlach, Agnes; Knaus, Ulla G; Daiber, Andreas
Abstract:
Reactive oxygen and nitrogen species (e.g. H2O2, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. In addition, classical regulation of gene expression or activity, including gene transcription to RNA followed by translation to the protein level, by transcription factors (e.g. NF-?B, HIF-1?) and mRNA binding proteins (e.g. GAPDH, HuR) is subject to redox regulation. This review will give an update...     »
Journal title abbreviation:
Redox Biol
Year:
2015
Journal volume:
5
Pages contribution:
275-89
Language:
eng
Fulltext / DOI:
doi:10.1016/j.redox.2015.05.008
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26079210
TUM Institution:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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