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Title:

Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Chalupsky, Karel; Kra?un, Damir; Kanchev, Ivan; Bertram, Katharina; Görlach, Agnes
Abstract:
Nitric oxide (NO) derived from endothelial NO synthase (eNOS) has been implicated in the adaptive response to hypoxia. An imbalance between 5,6,7,8-tetrahydrobiopterin (BH4) and 7,8-dihydrobiopterin (BH2) can result in eNOS uncoupling and the generation of superoxide instead of NO. Dihydrofolate reductase (DHFR) can recycle BH2 to BH4, leading to eNOS recoupling. However, the role of DHFR and eNOS recoupling in the response to hypoxia is not well understood. We hypothesized that increasing the c...     »
Journal title abbreviation:
Antioxid Redox Signal
Year:
2015
Journal volume:
23
Journal issue:
14
Pages contribution:
1076-91
Language:
eng
Fulltext / DOI:
doi:10.1089/ars.2015.6329
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26414244
Print-ISSN:
1523-0864
TUM Institution:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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